Friday, January 13, 2012

Can someone please translate this for me? tia...?

A second presentation (“Correlation of progression-free survival and overall survival in men with metastatic castration-resistant prostate cancer who failed first-line chemotherapy: results from the SPARC trial,” Halabi et al, Abstract #5150) evaluated whether PFS at three months was predictive of OS and explored the statistical dependencies between PFS and OS. Of the 853 men alive at three months post-randomization, 477 (56%) had already progressed. The median survival for this group was 34.5 weeks versus 78.7 weeks in men who had not progressed at the same three month timepoint. [hazard ratio: 2.16 (95% CI =1.84-2.55), p-value <0.001]. The dependence between PFS and OS was 0.29 (95% confidence limits = 0.24-0.33, p-value < 0.00001). Thus PFS at three months predicts OS. Additional studies will be needed to ess the clinical relevance of the individual components of progression as defined in the SPARC trial to OS.

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